CX3CR1 (cx3c1_human)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors CX3CR1
GENE
CX3CR1 (ECO:0000312|HGNC:HGNC:2558}, CMKBRL1, GPR13)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
CX3C chemokine receptor 1, C-X3-C CKR-1, CX3CR1, Beta chemokine receptor-like 1, CMK-BRL-1, CMK-BRL1, Fractalkine receptor, G-protein coupled receptor 13, V28
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
Q
|
F
|
P
|
E
|
S
|
V
|
T
|
E
|
10 |
N
|
F
|
E
|
Y
|
D
|
D
|
L
|
A
|
E
|
A
|
20 |
TM1 | |||||||||
C
|
Y
|
I
|
G
|
D
|
I
|
V
|
V
|
F
|
G
|
30 |
T
|
V
|
F
|
L
|
S
|
I
|
F
|
Y
|
S
|
V
|
40 |
I
|
F
|
A
|
I
|
G
|
L
|
V
|
G
|
N
|
L
|
50 |
L
|
V
|
V
|
F
|
A
|
L
|
T
|
N
|
S
|
K
|
60 |
ICL1 | TM2 | ||||||||
K
|
P
|
K
|
S
|
V
|
T
|
D
|
I
|
Y
|
L
|
70 |
L
|
N
|
L
|
A
|
L
|
S
|
D
|
L
|
L
|
F
|
80 |
V
|
A
|
T
|
L
|
P
|
F
|
W
|
T
|
H
|
Y
|
90 |
ECL1 | |||||||||
L
|
I
|
N
|
E
|
K
|
G
|
L
|
H
|
N
|
A
|
100 |
TM3 | |||||||||
M
|
C
|
K
|
F
|
T
|
T
|
A
|
F
|
F
|
F
|
110 |
I
|
G
|
F
|
F
|
G
|
S
|
I
|
F
|
F
|
I
|
120 |
T
|
V
|
I
|
S
|
I
|
D
|
R
|
Y
|
L
|
A
|
130 |
ICL2 | |||||||||
I
|
V
|
L
|
A
|
A
|
N
|
S
|
M
|
N
|
N
|
140 |
TM4 | |||||||||
R
|
T
|
V
|
Q
|
H
|
G
|
V
|
T
|
I
|
S
|
150 |
L
|
G
|
V
|
W
|
A
|
A
|
A
|
I
|
L
|
V
|
160 |
A
|
A
|
P
|
Q
|
F
|
M
|
F
|
T
|
K
|
Q
|
170 |
ECL2 | |||||||||
K
|
E
|
N
|
E
|
C
|
L
|
G
|
D
|
Y
|
P
|
180 |
TM5 | |||||||||
E
|
V
|
L
|
Q
|
E
|
I
|
W
|
P
|
V
|
L
|
190 |
R
|
N
|
V
|
E
|
T
|
N
|
F
|
L
|
G
|
F
|
200 |
L
|
L
|
P
|
L
|
L
|
I
|
M
|
S
|
Y
|
C
|
210 |
Y
|
F
|
R
|
I
|
I
|
Q
|
T
|
L
|
F
|
S
|
220 |
ICL3 | TM6 | ||||||||
C
|
K
|
N
|
H
|
K
|
K
|
A
|
K
|
A
|
I
|
230 |
K
|
L
|
I
|
L
|
L
|
V
|
V
|
I
|
V
|
F
|
240 |
F
|
L
|
F
|
W
|
T
|
P
|
Y
|
N
|
V
|
M
|
250 |
I
|
F
|
L
|
E
|
T
|
L
|
K
|
L
|
Y
|
D
|
260 |
ECL3 | TM7 | ||||||||
F
|
F
|
P
|
S
|
C
|
D
|
M
|
R
|
K
|
D
|
270 |
L
|
R
|
L
|
A
|
L
|
S
|
V
|
T
|
E
|
T
|
280 |
V
|
A
|
F
|
S
|
H
|
C
|
C
|
L
|
N
|
P
|
290 |
H8 | |||||||||
L
|
I
|
Y
|
A
|
F
|
A
|
G
|
E
|
K
|
F
|
300 |
R
|
R
|
Y
|
L
|
Y
|
H
|
L
|
Y
|
G
|
K
|
310 |
C-term | |||||||||
C
|
L
|
A
|
V
|
L
|
C
|
G
|
R
|
S
|
V
|
320 |
H
|
V
|
D
|
F
|
S
|
S
|
S
|
E
|
S
|
Q
|
330 |
R
|
S
|
R
|
H
|
G
|
S
|
V
|
L
|
S
|
S
|
340 |
N
|
F
|
T
|
Y
|
H
|
T
|
S
|
D
|
G
|
D
|
350 |
A
|
L
|
L
|
L
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
CX3CL1
STRUCTURE MODELS
STRUCTURES
Found 2 structure(s) - view all details on the Structures page